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Survey on deep learning for pulmonary medical imaging
Jiechao Ma, Yang Song, Xi Tian, Yiting Hua, Rongguo Zhang, Jianlin Wu
《医学前沿(英文)》 2020年 第14卷 第4期 页码 450-469 doi: 10.1007/s11684-019-0726-4
关键词: deep learning neural networks pulmonary medical image survey
Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 425-432 doi: 10.1007/s11684-013-0295-x
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality throughout the world and is mainly characterized by persistent airflow limitation. Given that multiple systems other than the lung can be impaired in COPD patients, the traditional FEV1/FVC ratio shows many limitations in COPD diagnosis and assessment. Certain heterogeneities are found in terms of clinical manifestations, physiology, imaging findings, and inflammatory reactions in COPD patients; thus, phenotyping can provide effective information for the prognosis and treatment. However, phenotypes are often based on symptoms or pathophysiological impairments in late-stage COPD, and the role of phenotypes in COPD prevention and early diagnosis remains unclear. This shortcoming may be overcome by the potential genotypes defined by the heterogeneities in certain genes. This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations between genotypes and phenotypes. The potential roles of these genotypes and phenotypes in the molecular mechanisms and management of COPD are also elucidated.
关键词: chronic obstructive pulmonary disease heterogeneity phenotype genotype prediction
孔鸣,何前锋,李兰娟
《中国工程科学》 2018年 第20卷 第2期 页码 86-91 doi: 10.15302/J-SSCAE-2018.02.013
医疗健康数据的融合、开放共享,利用人工智能对碎片化医学信息进行整理分析,对医疗诊断过程提供辅助,可改善医疗健康服务,促进政府决策合理化,缓解医疗卫生资源配置不均衡问题。本文选取健康医疗信息人机交互、数据智能中的语义理解与医学影像分析等方面,简要阐述了人工智能在辅助诊疗问题上的发展方向与现状,讨论了智能诊疗技术发展与应用的问题与挑战:一是医学信息的标准化表征和结构化整合构建术语标准是关键;二是利用海量医学知识,构建多模态数据采集分析与结构化知识推理相结合的智能诊疗模型是重要的影像智能发展点。建议建立国家级的健康医疗开放大数据云平台,开辟新的数据、信息整合、知识发现及服务市场;构建医疗健康信息的一些基础行业标准,加强国产高端医疗器械的研发力度,推动智能化医疗器械和智能可穿戴式设备的研发,引导产业在人工智能与高端医疗器械的结合上开辟新的市场。
Protein microspheres for pulmonary drug delivery
Yongda SUN,
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 82-86 doi: 10.1007/s11705-009-0307-1
关键词: advanced engineering improved pressure aqueous technique
沈楚云,李文浩,徐琪森,胡斌,金博,蔡海滨,朱凤平,李郁欣,王祥丰
《信息与电子工程前沿(英文)》 2023年 第24卷 第9期 页码 1332-1348 doi: 10.1631/FITEE.2200299
null
《医学前沿(英文)》 2013年 第7卷 第3期 页码 354-366 doi: 10.1007/s11684-013-0257-3
Due to the implementation of directly observed treatment strategy (DOTS), China has made a significant achievement in tackling the tuberculosis (TB) epidemic in the 1990s. However, only half of regions in China met or exceeded the 85% rate of treatment success target. The aim of the present study is to summarize the treatment outcomes of smear-positive pulmonary TB in the mainland of China in the past decade using meta-analysis based on systematic review of published observational studies. A total of 50 eligible articles (58 studies) were identified and included in this study. The summarized treatment success rates were 93.9% (95% CI, 92.8%–94.7%) for new cases and 85.4% (95% CI, 83.0%–87.6%) for previously treated cases, and the summarized cured rate were 92.2% (95% CI, 90.9%–93.3%) and 81.2% (95% CI, 79.1%–83.1%), respectively. A remarkable increase of rates for treatment success and cure was observed in the 1990s. After 2000, the summarized treatment outcomes were tending towards stability. In addition, geographic areas, type of the data and administrative level of the hospital were also found to influence the estimates of the treatment outcomes. Results of the present study clearly show, in general, that the pulmonary TB treatment achieved significant success in the past decade in the mainland of China. However, it needs to be further strengthened in the central and west areas.
Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive
null
《医学前沿(英文)》 2013年 第7卷 第3期 页码 395-395 doi: 10.1007/s11684-013-0289-8
Xiuxiu Wu, Wenshuai Xu, Jun Wang, Xinlun Tian, Zhuang Tian, Kaifeng Xu
《医学前沿(英文)》 2019年 第13卷 第2期 页码 259-266 doi: 10.1007/s11684-018-0634-z
关键词: lymphangioleiomyomatosis pulmonary hypertension pulmonary function hypoxemia sirolimus
Clinical characteristics of pulmonary hypertension in bronchiectasis
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 336-344 doi: 10.1007/s11684-016-0461-z
Pulmonary hypertension (PH), as a complication of bronchiectasis, is associated with increased mortality. However, hemodynamic characteristics and the efficacy of pulmonary arterial hypertension (PAH) therapies in patients with bronchiectasis and PH remain unknown. Patients with bilateral bronchiectasis and concurrent PH were included in the study. Patient characteristics at baseline and during follow-up, as well as survival, were analyzed. This observational study was conducted in 36 patients with a mean age of 51.5 years (range, 17?74 years). The 6 min walking distance was 300.8±93.3 m. The mean pulmonary arterial pressure (PAP) was 41.5±11.7 mmHg, cardiac output was 5.2±1.4 L/min, and pulmonary vascular resistance was 561.5±281.5 dyn·s·cm−5. The mean PAP was>35 mmHg in 75% of the cases. Mean PAP was inversely correlated with arterial oxygen saturation values (r = −0.45, P = 0.02). In 24 patients who received oral PAH therapy, systolic PAP was reduced from 82.4±27.0 mmHg to 65.5±20.9 mmHg (P = 0.025) on echocardiography after a median of 6 months of follow-up. The overall probability of survival was 97.1% at 1 year, 83.4% at 3 years, and 64.5% at 5 years. Given the results, we conclude that PH with severe hemodynamic impairment can occur in patients with bilateral bronchiectasis, and PAH therapy might improve hemodynamics in such patients. Prospective clinical trials focusing on this patient population are warranted.
ZHANG Xiaomei, JIANG Liangduo, ZHANG Wei, WU Jianjun, LU Xiangfeng
《医学前沿(英文)》 2008年 第2卷 第3期 页码 314-316 doi: 10.1007/s11684-008-0060-8
关键词: bleomycin intratracheal injection prednisone collagen bleomycin-induced pulmonary
Turbidity-adaptive underwater image enhancement method using image fusion
《机械工程前沿(英文)》 2022年 第17卷 第3期 doi: 10.1007/s11465-021-0669-8
关键词: turbidity underwater image enhancement image fusion underwater robots visibility
mycelium inhibits epithelial-mesenchymal transition by inactivating the midkine pathway in pulmonary
Li Lu, Haiyan Zhu, Hailin Wang, Huaping Liang, Yayi Hou, Huan Dou
《医学前沿(英文)》 2021年 第15卷 第2期 页码 313-329 doi: 10.1007/s11684-020-0737-1
关键词: epithelial−mesenchymal transition H. sinensis mycelium midkine pulmonary fibrosis
Yanhong Shou, Lu Yang, Yongsheng Yang, Xiaohua Zhu, Feng Li, Bo Yin, Yingyan Zheng, Jinhua Xu
《医学前沿(英文)》 2021年 第15卷 第4期 页码 585-593 doi: 10.1007/s11684-020-0817-2
关键词: Stevens–Johnson syndrome toxic epidermal necrolysis auxiliary score ABCD-10 pulmonary consolidation
null
《医学前沿(英文)》 2014年 第8卷 第3期 页码 368-375 doi: 10.1007/s11684-014-0360-0
This study aimed to evaluate the efficacy of comprehensive therapy based on traditional Chinese medicine (TCM) patterns on older patients with chronic obstructive pulmonary disease (COPD) through a four-center, open-label, randomized controlled trial. Patients were divided into the trial group treated using conventional western medicine and Bu-Fei Jian-Pi granules, Bu-Fei Yi-Shen granules, and Yi-Qi Zi-Shen granules based on TCM patterns respectively; and the control group treated using conventional western medicine. A total of 136 patients≥65 years completed the study, with 63 patients comprising the trial group and 73 comprising the control group. After the six-month treatment and the 12-month follow-up period, significant differences were observed between the trial and control groups in the following aspects: frequency of acute exacerbation (P≤0.040), duration of acute exacerbation (P = 0.034), symptoms (P≤0.034), 6-min walking distance (6MWD) (P≤0.039), dyspnea scale (P≤0.036); physical domain (P≤0.019), psychological domain (P≤0.033), social domain (P≤0.020), and environmental domain (P≤0.044) of the WHOQOL-BREF questionnaire; and daily living ability domain (P≤0.007), social activity domain (P≤0.018), depression symptoms domain (P≤0.025), and anxiety symptoms domain (P≤0.037) of the COPD-QOL. No differences were observed between the trial and control groups with regard to FVC, FEV1, and FEV1%.
关键词: chronic obstructive pulmonary disease older adult clinical trial Bu-Fei Jian-Pi granules Bu-Fei Yi-Shen granules Yi-Qi Zi-Shen granules
A literature review of perishable medical resource management
《工程管理前沿(英文)》 页码 710-726 doi: 10.1007/s42524-023-0278-9
关键词: perishable medical resources organ transplant healthcare products decision analytics operations management
标题 作者 时间 类型 操作
Survey on deep learning for pulmonary medical imaging
Jiechao Ma, Yang Song, Xi Tian, Yiting Hua, Rongguo Zhang, Jianlin Wu
期刊论文
Treatment outcomes of pulmonary tuberculosis in the past decade in the mainland of China: a meta-analysis
null
期刊论文
Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive
null
期刊论文
Clinical characteristics in lymphangioleiomyomatosis-related pulmonary hypertension: an observation on
Xiuxiu Wu, Wenshuai Xu, Jun Wang, Xinlun Tian, Zhuang Tian, Kaifeng Xu
期刊论文
Effect of Feixian Recipe on laminin, collagen I and III in rats with pulmonary fibrosis induced by bleomycin
ZHANG Xiaomei, JIANG Liangduo, ZHANG Wei, WU Jianjun, LU Xiangfeng
期刊论文
mycelium inhibits epithelial-mesenchymal transition by inactivating the midkine pathway in pulmonary
Li Lu, Haiyan Zhu, Hailin Wang, Huaping Liang, Yayi Hou, Huan Dou
期刊论文
Stevens–Johnson syndrome and toxic epidermal necrolysis in China: evaluation of risk models and new predictor of pulmonary
Yanhong Shou, Lu Yang, Yongsheng Yang, Xiaohua Zhu, Feng Li, Bo Yin, Yingyan Zheng, Jinhua Xu
期刊论文
comprehensive therapy based on traditional Chinese medicine patterns on older patients with chronic obstructive pulmonary
null
期刊论文